Key result
RVEF and PAP independently predict death or urgent heart transplantation in chronic heart failure.
Why the study?
Although RV systolic function was traditionally thought to depend almost exclusively on afterload, recent studies claimed it independently predicts prognosis in chronic heart failure. Better understanding the coupling between RVEF and PAP might improve risk stratification.
Do right ventricular ejection fraction and pulmonary artery pressure independently predict mortality or urgent transplantation in patients with chronic heart failure?
Population
377 consecutive patients with heart failure
Comparison
Assessment of RVEF and PAP via right heart catheterization
Design
Prospective cohort study
Follow-up
Median 17 +/- 9 months
Authors
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May enhance HF risk stratification; leaves open whether targeting RV function or PAP improves outcomes.
Cohort (n=377)
Do right ventricular ejection fraction and pulmonary artery pressure independently predict mortality or urgent transplantation in patients with chronic heart failure?
p-value: p=<0.001
Both right ventricular ejection fraction and pulmonary artery pressure provide independent and additive prognostic value in patients with chronic heart failure.
Ghio et al. (2001) conducted a cohort in chronic heart failure (n=377). Right ventricular ejection fraction and pulmonary artery pressure vs. Normal right ventricular ejection fraction and pulmonary artery pressure was evaluated on Death or urgent heart transplantation (p=<0.001). Right ventricular ejection fraction and pulmonary artery pressure were independent prognostic predictors of death or urgent heart transplantation in patients with chronic heart failure (p < 0.001).
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