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January 1, 1977The Journal of PhysiologyOpen Access

A large birefringence signal preceding contraction in single twitch fibres of the frog.

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Population

Single twitch fibres of the frog

Comparison

External stimulation to give a propagated action… vs Resting state or standard conditions

Design

Preclinical

Authors

SBStephen M. BaylorUniversity of PennsylvaniaHOH. OetlikerKantonsspital St. Gallen

Discussion

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Implication

Early birefringence signal may mark initial activation steps in amphibian muscle; leaves open relevance to mammalian cardiac excitation-contraction coupling.

Structured PICO

P
Population
Single twitch fibres of the frog
I
Intervention
External stimulation to give a propagated action potential (including variations with stretch, D2O, hypertonic solution, nitrate, and double-shock stimulation)
C
Comparator
Resting state or standard conditions (normal Ringer solution)
O
Outcome
Birefringence signal (change in light intensity) and its timing relative to tension developmentsurrogate

A large, early birefringence signal in frog muscle fibers precedes contraction and likely reflects steps in contractile activation.

Cite This Study

Baylor et al. (1977) studied this question.

synapsesocial.com/papers/6a7e8eaa4e6fc73b94b9893bhttps://doi.org/10.1113/jphysiol.1977.sp011661
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Also Consider

Synapse has enriched 4 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Muscle Compliance and the Longitudinal Transmission of Mechanical Impulses1974 · 50 citations
  2. 2Sarcomere lengthening and tension drop in the latent period of isolated frog skeletal muscle fibers.1976 · 43 citations
  3. 3The dependence of the latency relaxation on sarcomere length and other characteristics of isolated muscle fibres1972 · 40 citations
  4. 4Analysis of the potential‐dependent changes in optical retardation in the squid giant axon1971 · 96 citations