Supports altered central RAS in early hypertension development; hypothesis-generating in rats, no clinical translation yet.
Key Points
To investigate changes in brain and cerebrospinal fluid angiotensinogen levels across different developmental stages in genetically hypertensive rats compared to normotensive controls.
Measured angiotensinogen levels in brain regions and cerebrospinal fluid of spontaneously hypertensive rats (SHR) and normotensive Wistar-Kyoto (WKY) rats.
Assessed animals across three developmental time points: 4, 7, and 16 weeks of age.
Angiotensinogen levels were elevated in multiple brain regions of spontaneously hypertensive rats compared to WKY controls, primarily at 4 and 7 weeks of age.
Cerebrospinal fluid angiotensinogen concentrations did not correlate with regional brain tissue levels.