August 1, 2000Biochemical Society Transactions

Aminopeptidase A, which generates one of the main effector peptides of the brain renin-angiotensin system, angiotensin III, has a key role in central control of arterial blood pressure

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Population

Experimental animal models (murine brain renin-angiotensin system)

Comparison

Intracerebroventricular injection of… vs Intravenous injection, exogenous AngII alone, or…

Design

Preclinical

Authors

XIXavier IturriozCentre National de la Recherche Scientifique GVGilles VazeuxCommissariat à l'Énergie Atomique et aux Énergies Alternatives MFM C Fournié-ZaluskiPharmaleads (France)

Discussion

Member takes

Implication

May inform central APA inhibitor development in hypertension models; leaves open human translation of brain AngIII targeting.

Structured PICO

Population

Experimental animal models (murine brain renin-angiotensin system)

Intervention

Intracerebroventricular (i.c.v.) injection of aminopeptidase A (APA) inhibitor EC33 or aminopeptidase N (APN) inhibitor PC18

Comparator

Intravenous injection, exogenous AngII alone, or prior treatment with losartan

Outcome

Arterial blood pressuresurrogate

Angiotensin III is identified as a major effector peptide of the brain renin-angiotensin system, suggesting aminopeptidase A inhibitors could serve as central anti-hypertensive agents.

Cite This Study

Iturrioz et al. (2000) studied this question.

synapsesocial.com/papers/6a7e910bac06d68e91cd9d5e https://doi.org/10.1042/bst0280435

Topics

Hypertension management

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Aminopeptidase A, which generates one of the main effector peptides of the brain renin-angiotensin system, angiotensin III, has a key role in central control of arterial blood pressure

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Topics

Aminopeptidase A, which generates one of the main effector peptides of the brain renin-angiotensin system, angiotensin III, has a key role in central control of arterial blood pressure

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Topics

Also Consider