Why the study?
It remains unclear whether the association between obesity and AF is driven by obesity-related comorbidities or a potential direct effect of obesity itself.
Does obesity increase the risk of incident atrial fibrillation in a general patient population?
Population
392 146 patients in Germany
Comparison
Overweight and obesity vs normal weight
Design
Observational cohort study using multivariable Cox regression and causal mediation analysis
Follow-up
10 years
Authors
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Obesity-associated AF risk may persist beyond comorbidities; leaves open whether weight loss independently prevents incident AF in prospective trials.
Does obesity increase the risk of incident atrial fibrillation in a general patient population?
Obesity significantly increases the risk of incident atrial fibrillation, with a substantial proportion of the risk being a direct effect independent of traditional cardiometabolic comorbidities.
Sedighi et al. (2025) studied this question.
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