January 6, 2004Cardiovascular Research

Simvastatin reduces human atrial myofibroblast proliferation independently of cholesterol lowering via inhibition of RhoA

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Why the study?

Does simvastatin reduce proliferation in cultured human atrial myofibroblasts?

Structured PICO

Does simvastatin reduce proliferation in cultured human atrial myofibroblasts?

Population

Cultured cardiac myofibroblasts from biopsies of human right atrial appendage

Intervention

Simvastatin (0.1-1.0 micromol/l)

Comparator

Serum-induced proliferation without simvastatin (or with reversal agents)

Outcome

Myofibroblast proliferation (quantified by cell counting and cell cycle progression)surrogate

Simvastatin reduces human atrial myofibroblast proliferation independently of cholesterol synthesis via inhibition of RhoA geranylgeranylation, suggesting a potential mechanism for preventing adverse myocardial remodeling.

Discussion

No takes yet. Share an insight, caveat, or question.

Implication

Hypothesis-generating for statin effects on atrial fibrosis; does not support practice change without in vivo validation.

Cite This Study

Karen E. Porter (2004) studied this question.

synapsesocial.com/papers/6a7e95ce061146f178a6c2f5 https://doi.org/10.1016/j.cardiores.2003.11.032

View Full Paper

Ask AI

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Simvastatin reduces human atrial myofibroblast proliferation independently of cholesterol lowering via inhibition of RhoA

Structured PICO

Discussion

Implication

Cite This Study

Simvastatin reduces human atrial myofibroblast proliferation independently of cholesterol lowering via inhibition of RhoA

Structured PICO

Discussion

Implication

Cite This Study

Also Consider

Also Consider