Why the study?
Does simvastatin or fenofibrate reduce atrial fibrillation duration and atrial remodeling in a canine model of congestive heart failure?
Population
Dogs subjected to 2-week ventricular tachypacing to induce congestive heart failure, and in vitro atrial…
Comparison
Simvastatin or fenofibrate administered during… vs Ventricular tachypacing alone and non-paced…
Design
Preclinical
Follow-up
2 weeks
Authors
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Supports statin effects on atrial remodeling in canine CHF; hypothesis-generating and does not support clinical adoption.
Does simvastatin or fenofibrate reduce atrial fibrillation duration and atrial remodeling in a canine model of congestive heart failure?
Simvastatin, but not fenofibrate, attenuates CHF-induced atrial structural remodeling and AF promotion in a canine model, suggesting a potential role for statins in preventing the fibrotic AF substrate.
Shiroshita-Takeshita et al. (2007) studied this question.
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