Lack of Diuretic Efficiency (but Not Low Diuresis) Early in An Acutely Decompensated Heart Failure Episode Is Associated with Increased 180-Day Mortality
Why the study?
Does low diuretic efficiency early in an acutely decompensated heart failure episode predict increased 180-day all-cause mortality?
Population
170 patients with acutely decompensated heart failure and respiratory insufficiency admitted to the…
Comparison
Lowest diuretic efficiency defined as ≤140 mL of… vs Higher diuretic efficiency.
Design
Cohort
Follow-up
180 days
Authors
Discussion
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Member takes
Implication
Low early DE was associated with higher mortality only before NT-proBNP adjustment; leaves open its incremental prognostic value in ADHF.
Structured PICO
Does low diuretic efficiency early in an acutely decompensated heart failure episode predict increased 180-day all-cause mortality?
P
Population
170 patients with acutely decompensated heart failure (ADHF) and respiratory insufficiency admitted to the emergency room, mean age 76.2 ± 10.3 years, from a tertiary university hospital in Porto, Portugal.
I
Intervention
Lowest diuretic efficiency (DE) defined as ≤140 mL of diuresis per 40 mg of furosemide equivalents evaluated for a maximum of 3 h after emergency room admission.
C
Comparator
Higher diuretic efficiency (>140 mL/40 mg of furosemide equivalents).
O
Outcome
180-day all-cause mortality (ACM).hard clinical
Low diuretic efficiency in the first 3 hours of an ADHF episode is associated with increased 180-day mortality, though this association is attenuated when adjusting for NT-proBNP.
Cite This Study
Ferreira et al. (2017) studied this question.