Why the study?
Does diuretic withdrawal improve clinical and neurohumoral parameters in patients with chronic, stabilized heart failure and systolic dysfunction?
Population
26 stabilized heart failure patients with systolic dysfunction (ejection fraction <45%)
Design
Cohort
Follow-up
3 months
Authors
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Diuretic interruption may be feasible in select stabilized HFrEF; hypothesis-generating and should not yet change practice.
Does diuretic withdrawal improve clinical and neurohumoral parameters in patients with chronic, stabilized heart failure and systolic dysfunction?
Diuretic withdrawal in stabilized heart failure patients with reduced ejection fraction may be well-tolerated and is associated with improved renal function and reduced plasma renin activity.
Galve et al. (2005) studied this question.
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