Efficacy of Intravenous Chlorothiazide for Refractory Acute Decompensated Heart Failure Unresponsive to Adjunct Metolazone

45 patients with acute decompensated heart failure (ADHF) who had an inadequate response to high-dose loop diuretics and then received at least one dose of oral metolazone ≥5 mg followed by at least one dose of intravenous chlorothiazide 500 mg if the response to metolazone was considered inadequate.

Intravenous chlorothiazide 500 mg

Oral metolazone ≥5 mg (patients served as their own controls)

Net-negative urine output of 500 ml or greater during the 12 hours after the index dosesurrogate