Population
Normal and cardiomyopathic hamsters (32-wk-old hypertrophic BIO14.6 strain and dilated BIO53.58 strain)
Comparison
Molecular cloning of hamster BNP and ANP cDNAs… vs Normal hamsters
Design
Preclinical
Authors
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No immediate clinical implications; extends validation of BIO hamster strains as models for HF biomarker research.
Cardiomyopathic hamsters exhibit augmented ventricular BNP and ANP gene expression and elevated plasma BNP, mimicking human heart failure and serving as a useful model for cardiovascular disease research.
Tamura et al. (1994) studied this question.
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