Population
12 male Sprague-Dawley rats
Comparison
Low-salt diet (0.03% NaCl) for 13 days vs Normal-salt diet (0.3% NaCl) for 13 days
Design
Preclinical
Follow-up
13 days
Authors
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Challenges urinary AGT/ANG II as intrarenal RAS markers; leaves open translation to human disease states.
Physiological stimulation of the renin-angiotensin system by a low-salt diet increases plasma and intrarenal ANG II but does not increase urinary AGT or ANG II excretion rates or cause significant renal injury in rats.
Shao et al. (2013) studied this question.
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