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November 1, 1980Annals of Otology Rhinology & Laryngology

IV. Influence of Vestibular Stimulation

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Authors

PHPamela S. HuberUniversity at Buffalo, State University of New YorkIGIrwin A. GinsbergPresbyterian HospitalMRMichael D. Rudnick

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Implication

Animal experiment reveals unchanged neomycin ototoxicity under vestibular stimulation in guinea pigs, suggesting sensory transduction does not boost drug uptake via membrane permeability.

Key Points

  • To determine whether vestibular stimulation and the resulting sensory transduction process increase inner ear hair cell membrane permeability to neomycin, worsening drug toxicity.
  • Administered transtympanic dosages of neomycin to guinea pigs.
  • Subjected animals to either three hours of vestibular stimulation or complete immobilization following antibiotic delivery.
  • Evaluated cochlear and vestibular tissues for differences in hair cell damage patterns, extent of lesions, and dosage-response variability.
  • Neither the topographic pattern nor the overall degree of hair cell damage differed between stimulated and immobilized groups across dosage levels.
  • Vestibular stimulation caused a statistically significant decrease in the standard deviation of the mean dosage-damage response, likely due to fluid mixing that promoted consistent drug delivery.

Cite This Study

Huber et al. (1980) studied this question.

synapsesocial.com/papers/6a7e9d7cb71e98145362798fhttps://doi.org/10.1177/00034894800896s305
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Effect of intratympanic N-acetylcystein (NAC) on vestibulotoxicity model formed with intratympanic gentamicin in Guinea pigs2026
  2. 2Nobiletin protects hair cells against neomycin-induced vestibular hair cell death2024
  3. 3Immunoelectron microscopic analysis of neurotoxic effect of glutamate in the vestibular end organs during ischemia2012 · 8 citations
  4. 4Vestibular Hypofunction Secondary to Topical Use of Aminoglycosides in Ears with Perforated Tympanic Membrane2024 · 1 citations
  5. 5Early downregulation of hair cell (HC)-specific genes in the vestibular sensory epithelium during chronic ototoxicity2025 · 1 citations