May 1, 1991Journal of Neurochemistry

Binding of Brain and Atrial Natriuretic Peptides to Cultured Mouse Astrocytes and Effect on Cyclic GMP

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Population

Cultured mouse astrocytes in primary culture

Design

Preclinical

Authors

VYV.T.F. YeungChinese University of Hong Kong CLChun‐Kit LaiSan Francisco State University CCC. S. CockraChinese University of Hong Kong

Discussion

Member takes

Implication

Hypothesis-generating for BNP-preferring receptor subtypes in astrocytes; leaves open human CNS relevance.

Structured PICO

Population

Cultured mouse astrocytes in primary culture

Intervention

Porcine brain natriuretic peptide (pBNP) and human/rat atrial natriuretic peptide (ANP) analogues (hANP1-28, rANP1-28, and rANP5-28)

Outcome

Binding affinity, binding capacity, and cyclic GMP (cGMP) productionsurrogate

BNP and ANP bind to the same receptors on mouse astrocytes with similar affinity, but BNP induces significantly greater cGMP production, suggesting the existence of receptor subtypes.

Cite This Study

Yeung et al. (1991) studied this question.

synapsesocial.com/papers/6a7ea09d6cdd7a4db3026508 https://doi.org/10.1111/j.1471-4159.1991.tb02068.x

View Full Paper

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Binding of Brain and Atrial Natriuretic Peptides to Cultured Mouse Astrocytes and Effect on Cyclic GMP

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Binding of Brain and Atrial Natriuretic Peptides to Cultured Mouse Astrocytes and Effect on Cyclic GMP

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider