September 1, 1991The Journal of General PhysiologyOpen Access

On the mechanism of basal and agonist-induced activation of the G protein-gated muscarinic K+ channel in atrial myocytes of guinea pig heart.

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Population

Single atrial myocytes of guinea pig heart

Comparison

Application of intracellular GTP, GTP-gamma S… vs Absence of agonists or varying concentrations of…

Design

Preclinical

Authors

HIHiroyuki ItoAomori Rosai Hospital TST SugimotoNational Blood Transfusion Service IKIchiro KobayashiSapporo Medical University

Discussion

Member takes

Implication

Supports GTP-dependent IK.ACh gating in atrial myocytes; hypothesis-generating for muscarinic modulation in human arrhythmias.

Structured PICO

Population

Single atrial myocytes of guinea pig heart

Intervention

Application of intracellular GTP, GTP-gamma S, and acetylcholine

Comparator

Absence of agonists or varying concentrations of GDP and inhibitors (IAP, NEM)

Outcome

Activation and open probability of the G protein-gated muscarinic K+ channel (IK.ACh)surrogate

The study elucidates the mechanism of muscarinic K+ channel activation in atrial myocytes, showing that m-ACh receptor and G protein interaction is essential for basal stimulation and is enhanced by acetylcholine.

Cite This Study

Ito et al. (1991) studied this question.

synapsesocial.com/papers/6a7ea87eb2811efa75cda1d4 https://doi.org/10.1085/jgp.98.3.517

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On the mechanism of basal and agonist-induced activation of the G protein-gated muscarinic K+ channel in atrial myocytes of guinea pig heart.

Discussion

Member takes

Implication

Structured PICO

Cite This Study

On the mechanism of basal and agonist-induced activation of the G protein-gated muscarinic K+ channel in atrial myocytes of guinea pig heart.

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider