November 1, 1981American Journal of Clinical Pathology

Pathogenetic Aspects of Hepatitis A Virus Infection in Enterally Inoculated Marmosets

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Population

28 Saguinus mystax negative for antibody to HAV with statistically uniform baseline values of serum…

Design

Preclinical

Follow-up

Up to 32 days after inoculation and 35 days after SICD…

Authors

KKKrzysztof KrawczynskiCenters for Disease Control and Prevention DBDaniel W. BradleyEcological Society of America BMBert L. MurphyCenters for Disease Control and Prevention

Discussion

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Implication

Confirms hepatic HAV replication in marmosets; leaves open translation to human pathogenesis and therapy.

Structured PICO

Population

28 Saguinus mystax (marmosets) negative for antibody to HAV (anti-HAV) with statistically uniform baseline values of serum isocitrate dehydrogenase (SICD) activity

Intervention

Enteral (intragastric) inoculation with 1 ml of a 15% w/v stool suspension derived from marmosets infected with the third or fourth passage of the MS-1 strain of HAV

Outcome

Primary sites of HAV replication and immunopathology of the diseasesurrogate

This preclinical study demonstrates that the liver is the sole and primary site of hepatitis A virus replication following enteral inoculation in marmosets.

Cite This Study

Krawczynski et al. (1981) studied this question.

synapsesocial.com/papers/6a7eae37b2811efa75cda292 https://doi.org/10.1093/ajcp/76.5.698

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Pathogenetic Aspects of Hepatitis A Virus Infection in Enterally Inoculated Marmosets

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Pathogenetic Aspects of Hepatitis A Virus Infection in Enterally Inoculated Marmosets

Discussion

Member takes

Implication

Structured PICO

Cite This Study

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