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January 1, 1981Journal of VirologyOpen Access

Restricted replication of human hepatitis A virus in cell culture: intracellular biochemical studies

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Population

Vero cells

Comparison

Inoculation with human hepatitis A virus or its… vs Uninfected cells and cells infected with…

Design

Preclinical

Follow-up

Up to 48 hours postinfection

Authors

SLStephen LocarniniThe Royal Melbourne HospitalACA G CoulepisFairfield Infectious Diseases HospitalEWE. G. WestawayRoyal Children's Hospital

Discussion

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Implication

HAV shows restricted replication without progeny in Vero cells; leaves open identification of permissive systems for propagation studies.

Structured PICO

P
Population
Vero cells
I
Intervention
Inoculation with human hepatitis A virus or its extracted genomic RNA
C
Comparator
Uninfected cells (implied by subtraction method) and cells infected with poliovirus type 1 (for molecular weight comparison)
O
Outcome
Detection of virus-specified protein and RNA synthesissurrogate

Hepatitis A virus can undergo limited replication and protein synthesis in Vero cells without producing progeny virus or causing cytopathology.

Cite This Study

Locarnini et al. (1981) studied this question.

synapsesocial.com/papers/6a7eae37b2811efa75cda293https://doi.org/10.1128/jvi.37.1.216-225.1981
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Also Consider

Synapse has enriched 4 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Inhibition of host cell protein synthesis by UV-inactivated poliovirus1977 · 36 citations
  2. 2Gene Order of the Poliovirus Capsid Proteins1972 · 58 citations
  3. 3Proteins of the Group B Arbovirus Kunjin1969 · 48 citations
  4. 4The Relationship between a 27-nm Virus-Like Particle and Hepatitis A as Demonstrated by Immune Electron Microscopy1974 · 47 citations