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January 1, 1984Intervirology

Stability of Hepatitis A Virus

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Population

Hepatitis A virus (HAV) and poliovirus type 2

Comparison

Heating under controlled conditions of pH… vs Poliovirus type 2

Design

Preclinical

Authors

MWManfred WeitzUniversity of BernGKG. KronauerUniversity of Bern

Discussion

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Implication

May inform lab inactivation protocols; leaves open clinical translation from Level 5 data.

Structured PICO

P
Population
Hepatitis A virus (HAV) and poliovirus type 2
I
Intervention
Heating under controlled conditions of pH, temperature, and salt concentration (1 M MgCl2)
C
Comparator
Poliovirus type 2
O
Outcome
Temperature at which 50% of virus particles disintegrated during heating for 10 min (T50,10)surrogate

HAV is significantly more heat-stable than poliovirus type 2, though both are stabilized by magnesium chloride, and heating HAV leads to RNA release and eventual loss of serological reactivity.

Cite This Study

Weitz et al. (1984) studied this question.

synapsesocial.com/papers/6a7eae3ababc2b64f88b9b95https://doi.org/10.1159/000149554
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Acid Stability of Hepatitis A Virus1989 · 107 citations
  2. 2Long-term survival of hepatitis A virus and poliovirus type 1 in mineral water1988 · 106 citations
  3. 3Size and Conformational Stability of the Hepatitis a Virus used to Prepare VAQTA⊥, a Highly Purified Inactivated Vaccine1997 · 46 citations
  4. 4Inactivation of hepatitis a virus by heat treatment in aqueous solution1993 · 54 citations
  5. 5Effect of relative humidity and air temperature on survival of hepatitis A virus on environmental surfaces1991 · 216 citations