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September 1, 1993Journal of Medical Virology

Inactivation of hepatitis a virus by heat treatment in aqueous solution

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Why the study?

Does heat treatment at 60 degrees C for 10 hours inactivate hepatitis A virus in aqueous solutions?

Population

Cell culture-adapted hepatitis A virus suspended either in cell culture medium or in a proprietary…

Comparison

Heat treatment at 60 degrees C for 10 hours vs Poliovirus type 1

Design

Preclinical

Follow-up

10 hours

Authors

PMPaula C. MurphyUniversity of North Carolina at Chapel HillTNThomas NowakIndiana UniversitySLStanley M. LemonUniversity of North Carolina at Chapel Hill

Discussion

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Implication

Supports 60°C pasteurization reducing HAV risk in factor concentrates; leaves open stabilizer effects on residual infectivity.

Structured PICO

Does heat treatment at 60 degrees C for 10 hours inactivate hepatitis A virus in aqueous solutions?

P
Population
Cell culture-adapted hepatitis A virus (HAV) suspended either in cell culture medium or in a proprietary stabilizing buffer
I
Intervention
Heat treatment at 60 degrees C for 10 hours (pasteurization)
C
Comparator
Poliovirus type 1 (used as a reference for validation of virus inactivation)
O
Outcome
Reduction in the titer of infectious HAV (extent of infectivity reduction)surrogate

Pasteurization at 60°C for 10 hours significantly reduces HAV infectivity, though stabilizing buffers delay inactivation, suggesting pasteurized factor VIII concentrates pose little risk if initial viral loads are low.

Cite This Study

Murphy et al. (1993) studied this question.

synapsesocial.com/papers/6a87dfdd19ee2aac066c8e0chttps://doi.org/10.1002/jmv.1890410113
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Stability of Hepatitis A Virus1984 · 170 citations
  2. 2An Outbreak of Hepatitis A among Cancer Patients Treated with Interleukin-2 and Lymphokine-Activated Killer Cells1990 · 32 citations
  3. 3Antigenic and genetic variation in cytopathic hepatitis A virus variants arising during persistent infection: evidence for genetic recombination1991 · 211 citations
  4. 4Infectious Hepatitis1959 · 141 citations
  5. 5Virus safety of human immunoglobulins: Efficient inactivation of hepatitis C and other human pathogenic viruses by the manufacturing procedure1992 · 35 citations