Why the study?
Does the manufacturing process of solvent/detergent factor VIII reduce or inactivate hepatitis A virus in spiked human plasma?
Population
Human plasma and various factor VIII production intermediates spiked with cell culture-propagated hepatitis…
Design
Preclinical
Authors
Loading...
May support viral safety of factor VIII manufacturing; leaves open confirmation in human studies.
Does the manufacturing process of solvent/detergent factor VIII reduce or inactivate hepatitis A virus in spiked human plasma?
The manufacturing process for solvent/detergent factor VIII concentrate effectively reduces hepatitis A virus infectivity by 5.5 to 8.55 log10.
Lemon et al. (1994) studied this question.
Synapse has enriched 4 closely related papers on similar clinical questions. Consider them for comparative context: