November 1, 1995Hepatology

An outbreak of hepatitis A among south african patients with hemophilia: Evidence implicating contaminated factor VIII concentrate as the source

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Population

9 South African hemophiliacs treated exclusively with infusions of factor VIII concentrate

Design

Case_series

Authors

MKMary‐Anne KeddaTranslational Research Institute MKMichael C. KewUniversity of British Columbia RCRichard J. CohnThe University of Sydney

Discussion

Member takes

Implication

May signal HAV transmission risk via factor VIII; hypothesis-generating for plasma product safety.

Structured PICO

Population

9 South African hemophiliacs treated exclusively with infusions of factor VIII concentrate

Intervention

Factor VIII concentrate prepared by the solvent/detergent (S/D) method

Outcome

Hepatitis A virus (HAV) complementary DNA (cDNA) homology between patient serum and factor VIII concentratesurrogate

Factor VIII concentrate prepared by the solvent/detergent method may be contaminated by hepatitis A virus at the source and cause infection in recipients.

Limitations

Proof of a cause-and-effect relationship will depend on animal inoculation studies
Unknown whether patients with low homology acquired infection from other strains or extraneous sources

Cite This Study

Kedda et al. (1995) studied this question.

synapsesocial.com/papers/6a891e1feb3171c94f1ff97c https://doi.org/10.1002/hep.1840220504

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