June 1, 1994Vox Sanguinis
The Outbreak of Hepatitis A in Italian Patients with Hemophilia: Facts and Fancies
Key result
Receiving solvent-detergent treated factor VIII concentrate was associated with hepatitis A infection in hemophiliacs, with identical HAV sequences found in implicated lots and recipient serum.
Why the study?
Was the outbreak of hepatitis A in Italian hemophiliacs acquired through the infusion of contaminated factor VIII or through environmental enteric transmission?
Population
52 Italian hemophiliacs with a hepatitis A outbreak; case-control study included the first 29 infected…
Comparison
Factor VIII concentrate treated with… vs Hemophiliacs without HAV infection (controls)
Design
Case-control
Authors
Discussion
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Implication
Supports caution with solvent-detergent treated factor VIII; leaves open optimal inactivation strategies for plasma products.
Study Design
Type
Case-Control
Structured PICO
Was the outbreak of hepatitis A in Italian hemophiliacs acquired through the infusion of contaminated factor VIII or through environmental enteric transmission?
P
Population
Case-control study of 29 Italian hemophiliacs infected with hepatitis A and uninfected hemophiliac controls to determine the source of an HAV outbreak.
E
Exposure
Factor VIII concentrate treated with solvent-detergent
C
Comparator
Hemophiliacs without HAV infection (controls)
O
Outcome
Hepatitis A (HAV) infection source and transmission route
The outbreak of Hepatitis A in Italian hemophiliacs was directly linked to the transmission of HAV through contaminated factor VIII concentrates treated with solvent-detergent.
Cite This Study
Mannucci et al. (1994) conducted a case-control in Hemophilia and Hepatitis A. Factor VIII concentrate treated with solvent-detergent vs. Hemophiliacs without HAV infection was evaluated on Source of HAV infection. Receiving solvent-detergent treated factor VIII concentrate was associated with hepatitis A infection in hemophiliacs, with identical HAV sequences found in implicated lots and recipient serum.