Key result
Exposure to clotting factor VIII lot no. 1950177 was significantly associated with an outbreak of hepatitis A among haemophilia patients (OR 35.0).
Why the study?
Is exposure to specific lots of blood clotting factors associated with hepatitis A virus infection in haemophilia patients?
Population
123 haemophilia patients in Korea who received clotting factor prescriptions between October 1998 and…
Comparison
Injection of specific lots of blood clotting… vs Injection of other lots of blood clotting factors.
Design
Case-control
Authors
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Prompts lot tracing in haemophilia HAV cases; leaves open vaccination policy changes pending confirmatory data.
Case-Control (n=123)
Is exposure to specific lots of blood clotting factors associated with hepatitis A virus infection in haemophilia patients?
Odds Ratio: 35 (95% CI 11.3–108.9)
Absolute Event Rate: 71% vs 6.5%
p-value: p=<0.01
The study identified a specific lot of clotting factor VIII as the source of a hepatitis A outbreak among haemophilia patients in Korea, highlighting the need for HAV vaccination in this population.
Jee et al. (2005) conducted a case-control in Haemophilia with acute hepatitis A (n=123). Clotting factor VIII lot no. 1950177 vs. Unexposed to this specific lot was evaluated on Acute hepatitis A infection (OR 35.0, 95% CI 11.3-108.9, p=<0.01). Exposure to clotting factor VIII lot no. 1950177 was significantly associated with an outbreak of hepatitis A among haemophilia patients (OR 35.0).
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