Why the study?
Current interventions for myocardial ischemia-reperfusion injury target a single pathology and fail to regulate later-stage repair, highlighting the need to summarize macrophage mechanisms and potential macrophage-centric targeted therapies.
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Design
Review
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Should not yet change practice; leaves open human trials of macrophage-targeted therapies for reperfusion injury.
Liu et al. (2025) studied this question.
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