August 10, 2011AJP Endocrinology and MetabolismOpen Access

Cardiac proteasome activity in muscle ring finger-1 null mice at rest and following synthetic glucocorticoid treatment

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Population

6-month-old wild-type (WT) and MuRF1 knockout (KO) mice

Comparison

Dexamethasone (Dex) treatment for 28 days vs Untreated state (rest) and WT mice

Design

Preclinical

Follow-up

28 days

Authors

DHDarren T. HweeCytokinetics (United States)AGAldrin V. GomesHeart Failure / Cardiomyopathy SBSue C. BodineUniversity of Iowa

Discussion

Member takes

Implication

Glucocorticoid-induced cardiac atrophy occurs independently of MuRF1 in mice; leaves open its role in human cardiac remodeling.

Structured PICO

Population

6-month-old wild-type (WT) and MuRF1 knockout (KO) mice

Intervention

Dexamethasone (Dex) treatment for 28 days

Comparator

Untreated state (rest) and WT mice

Outcome

Cardiac function, architecture, and proteasome activitysurrogate

MuRF1 plays an important role in regulating cardiac size through alterations in protein turnover, but is not required to induce cardiac atrophy following synthetic glucocorticoid treatment.

Cite This Study

Hwee et al. (2011) studied this question.

synapsesocial.com/papers/6a7eb503ed99481a4b338d91 https://doi.org/10.1152/ajpendo.00165.2011

View Full Paper

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Cardiac proteasome activity in muscle ring finger-1 null mice at rest and following synthetic glucocorticoid treatment

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Cardiac proteasome activity in muscle ring finger-1 null mice at rest and following synthetic glucocorticoid treatment

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider