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October 12, 2005International ImmunologyOpen Access

Antigenic structures recognized by anti-β2-glycoprotein I auto-antibodies

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Population

Beta2-glycoprotein I (beta2-GPI) crystal structure and phage-displayed random peptide library

Comparison

Amino acid replacement and molecular dynamics… vs Unmodified beta2-GPI

Design

Preclinical

Authors

HKHideki KasaharaHokkaido UniversityEMEiji MatsuuraOkayama UniversityKKKeiko KaiharaOkayama University

Discussion

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Overview

Hypothesis-generating for epitope mapping in APS; leaves open human translation and therapeutic targeting.

Structured PICO

P
Population
Beta2-glycoprotein I (beta2-GPI) crystal structure and phage-displayed random peptide library
I
Intervention
Amino acid replacement (L replacement for W235, or V replacement for D193, D222, and E228) and molecular dynamics simulation
C
Comparator
Unmodified beta2-GPI
O
Outcome
Binding of anti-beta2-GPI auto-antibodies to solid-phase beta2-GPI and identification of epitopic structuressurrogate

Epitopic structures recognized by anti-beta2-GPI auto-antibodies are cryptic, and inter-domain electrostatic interactions between domains IV and V are involved in their exposure.

Cite This Study

Kasahara et al. (2005) studied this question.

synapsesocial.com/papers/6a7eb660a11f4f846b8ec86dhttps://doi.org/10.1093/intimm/dxh330
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Identification of a region of beta 2-glycoprotein I critical for lipid binding and anti-cardiolipin antibody cofactor activity.1993 · 180 citations
  2. 2Anticardiolipin antibodies recognize beta 2-glycoprotein I structure altered by interacting with an oxygen modified solid phase surface.1994 · 531 citations
  3. 3<scp>CHARMM</scp>: A program for macromolecular energy, minimization, and dynamics calculations1983 · 15,018 citations
  4. 4Anti-β2 glycoprotein I (β2GPI) autoantibodies recognize an epitope on the first domain of β2GPI1998 · 232 citations
  5. 5Amino acid sequence and location of the disulfide bonds in bovine .beta.2 glycoprotein I: the presence of five Sushi domains1991 · 133 citations