The integrity of the C-terminal region of beta 2-glycoprotein I (residues 317-318) is critical for its ability to bind negatively charged phospholipids and act as a cofactor for anti-cardiolipin antibodies.
No takes yet. Share an insight, caveat, or question.
Does not support clinical changes in antiphospholipid syndrome; hypothesis-generating for C-terminal targeting of beta 2-GPI.
Hunt et al. (1993) studied this question.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: