February 1, 1994The Journal of Experimental MedicineOpen Access

Anticardiolipin antibodies recognize beta 2-glycoprotein I structure altered by interacting with an oxygen modified solid phase surface.

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Population

Sera from 40 patients with antiphospholipid syndrome (APS) and (NZW x BXSB)F1 mice

Comparison

beta 2-glycoprotein I adsorbed to an oxidized… vs Unmodified surfaces, excess beta 2-GPI, CL…

Design

Preclinical

Authors

EMEiji MatsuuraOkayama University YIYoshiko IgarashiGunma University TYTatsuji YasudaOkayama University

Discussion

Member takes

Implication

Supports assay equivalence in APS; leaves open whether epitope-specific ELISAs improve diagnostics or management.

Structured PICO

Population

Sera from 40 patients with antiphospholipid syndrome (APS) and (NZW x BXSB)F1 mice

Intervention

beta 2-glycoprotein I (beta 2-GPI) adsorbed to an oxidized polystyrene surface (irradiated with electron or gamma-ray radiation)

Comparator

Unmodified surfaces, excess beta 2-GPI, CL micelles, or CL-coated latex beads alone

Outcome

Binding of anticardiolipin antibodies (aCL) to beta 2-GPIsurrogate

Anticardiolipin antibodies specifically recognize a conformational epitope on beta 2-glycoprotein I that is exposed when it interacts with an oxygen-substituted solid phase surface.

Cite This Study

Matsuura et al. (1994) studied this question.

synapsesocial.com/papers/6a893acec29c9b72f7c10e1f https://doi.org/10.1084/jem.179.2.457

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Anticardiolipin antibodies recognize beta 2-glycoprotein I structure altered by interacting with an oxygen modified solid phase surface.

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Anticardiolipin antibodies recognize beta 2-glycoprotein I structure altered by interacting with an oxygen modified solid phase surface.

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider