Key result
Four out of six beta 2 glycoprotein I dependent anticardiolipin antibodies affinity purified from patients demonstrated lupus anticoagulant activity.
Population
Six anticardiolipin antibodies affinity purified from patients with these antibodies and lupus anticoagulant…
Design
Preclinical
Authors
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Some aCL antibodies exhibit LA activity; hypothesis-generating for APS mechanisms, requires human validation.
Some beta 2 glycoprotein I dependent anticardiolipin antibodies possess lupus anticoagulant activity, though the mechanism for this heterogeneity remains unclear.
Keeling et al. (1993) studied Lupus anticoagulant / Antiphospholipid antibodies (n=6). Beta 2 glycoprotein I dependent anticardiolipin antibodies was evaluated on Lupus anticoagulant activity in the dilute Russell viper venom time test. Four out of six beta 2 glycoprotein I dependent anticardiolipin antibodies affinity purified from patients demonstrated lupus anticoagulant activity.
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