Key result
Autoimmune IgG anticardiolipin binding was enhanced by beta 2-glycoprotein I and showed significant reductions in functional affinity compared to individuals with malaria or AIDS.
Population
Affinity-purified anticardiolipin IgG from patients with autoimmune disease, malaria, and acquired…
Comparison
Incorporation of increasing amounts of beta… vs aCL IgG from individuals with malaria and AIDS
Design
Other
Authors
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Distinguishes autoimmune from infection-related aCL in vitro; hypothesis-generating for affinity-based testing and leaves clinical utility open pending validation.
Observational
Beta 2-glycoprotein I requirement for binding to cardiolipin varies inversely with functional affinity in autoimmune disease, suggesting greater heterogeneity of IgG aCL in autoimmune disorders compared to infectious diseases.
Dueymes et al. (1995) conducted an observational in Autoimmune disease, malaria, and AIDS. Autoimmune disease vs. Malaria and AIDS was evaluated on Binding capacity to cardiolipin and functional affinity of aCL IgG. Autoimmune IgG anticardiolipin binding was enhanced by beta 2-glycoprotein I and showed significant reductions in functional affinity compared to individuals with malaria or AIDS.
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