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January 1, 1998Thrombosis and Haemostasis

Heterogeneity and Immunochemical Properties of Anti-β2-glycoprotein I Autoantibodies

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Key result

The mode of presentation of beta2-glycoprotein I greatly influences its recognition by anti-beta2GPI antibodies, revealing marked inter-individual heterogeneity in 56 sera from APS patients.

Authors

VRVéronique RegnaultInsermÉHÉ. HachullaUniversité Claude Bernard Lyon 1LDLuc DarnigeUniversité Paris Cité

Discussion

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Overview

Presentation mode and inter-patient heterogeneity may confound anti-β2GPI testing in APS; leaves open assay standardization needs.

Study Design

Type

Observational (n=56)

PICO

P
Population
56 selected sera from patients with antiphospholipid syndrome analyzed for anti-beta2-glycoprotein I autoantibodies.
E
Exposure / Comparator
Beta2-glycoprotein I presentation
O
Primary Outcome
Reactivity profiles of anti-beta2GPI antibodies to human and bovine beta2GPI

Cite This Study

Regnault et al. (1998) conducted an observational in Antiphospholipid syndrome (APS) (n=56). Beta2-glycoprotein I presentation was evaluated on Reactivity profiles of anti-beta2GPI antibodies to human and bovine beta2GPI. The mode of presentation of beta2-glycoprotein I greatly influences its recognition by anti-beta2GPI antibodies, revealing marked inter-individual heterogeneity in 56 sera from APS patients.

synapsesocial.com/papers/6a9433c6beaf7a0a159c600dhttps://doi.org/10.1055/s-0037-1615218
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Anticardiolipin antibodies recognize beta 2-glycoprotein I structure altered by interacting with an oxygen modified solid phase surface.1994 · 531 citations
  2. 2Changes in β2-Glycoprotein I Antigenicity Induced by Phospholipid Binding1993 · 67 citations
  3. 3"Anticardiolipin" autoantibodies recognize beta2-glycoprotein I in the absence of phospholipid. Importance of Ag density and bivalent binding.1995 · 332 citations
  4. 4Development of an ELISA for Autoantibodies to Prothrombin Showing their Prevalence in Patients with Lupus Anticoagulants1995 · 212 citations
  5. 5Lupus‐like anticoagulant properties of murine monoclonal antibodies to β2‐glycoprotein I1992 · 53 citations