Synapse
⌘+K
Synapse
PulseExploreClubsResearchersJournals
Instagram
HomeClubsExplore
January 1, 1994The Journal of Immunology

The fifth domain of beta 2-glycoprotein I contains a phospholipid binding site (Cys281-Cys288) and a region recognized by anticardiolipin antibodies.

View Full Paper
Ask AI
Bookmark
Share

Population

In vitro model using synthetic peptides of beta 2-glycoprotein I and anticardiolipin antibodies purified…

Comparison

Synthetic peptides spanning the fifth domain of… vs Peptides from other regions, peptides with…

Design

Preclinical

Authors

JHJohn HuntSKSA Krilis

Discussion

Loading...

Member takes

Overview

Hypothesis-generating for APS mechanisms; requires human validation before any diagnostic or therapeutic application.

Structured PICO

P
Population
In vitro model using synthetic peptides of beta 2-glycoprotein I and anticardiolipin antibodies purified from patients with autoimmune disease
I
Intervention
Synthetic peptides spanning the fifth domain of beta 2-glycoprotein I (specifically Cys281-Cys288)
C
Comparator
Peptides from other regions, peptides with altered cysteine residues, and cleaved beta 2-glycoprotein I
O
Outcome
Binding of beta 2-glycoprotein I to cardiolipin and recognition by anticardiolipin antibodiessurrogate

Identifies the specific phospholipid binding site and putative epitope for anticardiolipin antibodies on beta 2-glycoprotein I, providing mechanistic insight into antiphospholipid syndrome.

Cite This Study

Hunt et al. (1994) studied this question.

synapsesocial.com/papers/6a762c20cd662f67b2fbdf00https://doi.org/10.4049/jimmunol.152.2.653
View Full Paper
Ask AI
Bookmark
Share

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Identification of a region of beta 2-glycoprotein I critical for lipid binding and anti-cardiolipin antibody cofactor activity.1993 · 180 citations
  2. 2Anticardiolipin and Anti-β2-GPI Are Two Distinct Populations of Autoantibodies1996 · 32 citations
  3. 3Antigenic structures recognized by anti-β2-glycoprotein I auto-antibodies2005 · 31 citations
  4. 4β<sub>2</sub>‐Glycoprotein i reactivity of monoclonal anticardiolipin antibodies from patients with the antiphospholipid syndrome1994 · 149 citations
  5. 5Anticardiolipin antibodies recognize beta 2-glycoprotein I structure altered by interacting with an oxygen modified solid phase surface.1994 · 531 citations