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November 1, 1975The Journal of PhysiologyOpen Access

Loss of alpha‐bungarotoxin from junctional and extrajunctional acetylcholine receptors in rat diaphragm muscle in vivo and in organ culture.

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Population

Rat diaphragm muscle (normal, denervated, and neonatal rats)

Comparison

Intrathoracic injection of alpha-bungarotoxin or… vs Junctional versus extrajunctional regions…

Design

Preclinical

Follow-up

up to 24 hours in culture

Authors

DBD K BergUniversity of California, San DiegoZHZach W. HallUniversity of California, San Francisco

Discussion

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Overview

Differential AChR turnover in denervated vs normal muscle leaves open translational relevance to human neuromuscular disorders; prospective studies required.

Structured PICO

P
Population
Rat diaphragm muscle (normal, denervated, and neonatal rats)
I
Intervention
Intrathoracic injection of alpha-bungarotoxin or [125I]alpha-bungarotoxin
C
Comparator
Junctional versus extrajunctional regions; normal versus denervated muscles
O
Outcome
Loss of toxin from acetylcholine receptors (half-time)surrogate

The study demonstrates a significant difference in turnover rates between junctional and extrajunctional acetylcholine receptors in rat diaphragm muscle.

Cite This Study

Berg et al. (1975) studied this question.

synapsesocial.com/papers/6a7eb6fa768d2d1c2a973aa1https://doi.org/10.1113/jphysiol.1975.sp011169
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Also Consider

Synapse has enriched 3 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Binding of α-Bungarotoxin to Acetylcholine Receptors In Mammalian Muscle1972 · 286 citations
  2. 2Acetylcholine Receptors1972 · 277 citations
  3. 3Acetylcholine receptors in normal and denervated rat diaphragm muscle. II. Comparison of junctional and extrajunctional receptors1975 · 197 citations