Key result
Muscle denervation was associated with increased specific alpha-Btx binding in 7 of 8 biopsies (up to 21 fmol/mg), whereas 10 control biopsies showed low (≤1 fmol/mg) or no specific binding.
Why the study?
Can in vitro autoradiography with 3H-alpha-bungarotoxin quantify extrajunctional acetylcholine receptors to demonstrate denervation in human muscle biopsies?
Observational (n=18)
Can in vitro autoradiography with 3H-alpha-bungarotoxin quantify extrajunctional acetylcholine receptors to demonstrate denervation in human muscle biopsies?
In vitro autoradiography with 3H-alpha-bungarotoxin can quantitatively measure extrajunctional acetylcholine receptors to assess denervation in human muscle biopsies.
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Suggests nicotinic receptor upregulation in denervated human muscle; hypothesis-generating and should not yet change practice.
Askmark et al. (1991) conducted an observational in Muscle denervation (n=18). Muscle denervation vs. Control biopsies (no denervation) was evaluated on Specific alpha-Btx binding (extrajunctional acetylcholine receptors). Muscle denervation was associated with increased specific alpha-Btx binding in 7 of 8 biopsies (up to 21 fmol/mg), whereas 10 control biopsies showed low (≤1 fmol/mg) or no specific binding.
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