Literature review reveals determinants of left ventricular remodeling after myocardial infarction, highlighting microvascular function as a crucial prognostic marker.
Hirayama A, Adachi T, Asada S, et al : Late reperfusion for acute myocardial infarction limits the dilatation of left ventricle without the reduction of infarct size. Circulation 1993; 88 : 2565–2574. Article CAS Google Scholar St John Sutton M, Pfeffer MA, Moye L, et al : Cardiovascular death and left ventricular remodeling two years after myocardial infarction: baseline predictors and impact of long-term use of captopril: information from the Survival and Ventricular Enlargement (SAVE) trial. Circulation 1997; 96 : 3294–3299. Article CAS Google Scholar Garot P, Pascal O, Simon M, et al : Impact of microvascular integrity and local viability on left ventricular remodeling after reperfused acute myocardial infarction. Heart 2003; 89 : 393–397. Article CAS Google Scholar Ohara M, Yukiiri K, Masugata H, et al : Relationship between myocardial flow reserve by oxygen-15 water positron emission tomography in the subacute phase after myocardial infarction and the left ventricular remodeling in the chronic phase. Hypertens Res 2008; 31 : 1307–1313. Article Google Scholar Jugdutt BI, Jelani A : Aging and defective healing, adverse remodeing, and blunted post-conditioning in the reperfused wounded heart. J Am Coll Cardiol 2008; 51 : 1399–1403. Article Google Scholar Yaoita H, Yoshinari K, Maehara K, Sando M, Watanabe K, Maruyama Y : Different effects of a high-cholesterol diet on ischemic cardiac dysfunction and remodeling induced by coronary stenosis and coronary occlusion. J Am Coll Cardiol 2005; 45 : 2078–2087. Article CAS Google Scholar Lipinski MJ, Biondi-Zoccai GGL, Abbate A, et al : Impact of intracoronary cell therapy on left ventricular function in the setting of acute myocardial infarction. J Am Coll Cardiol 2007; 50 : 1761–1767. Article Google Scholar Erbs S, Linke A, Schachinger V, et al : Restoration of microvascular function in the infarct-related artery by intracoronary transplantation of bone marrow progenitor cells in patients with acute myocardial infarction: the Doppler Substudy of the Reinfusion of Enriched Progenitor Cells and Infarct Remodeling in Acute Myocardial Infarction (REPAIR-AMI) trial. Circulation 2007; 116 : 366–374. Article Google Scholar Maggioni AP, Maseri A, Fresco C, et al : Age-related increase in mortality among patients with first myocardial infarctions treated with thrombolysis. The Investigators of the Gruppo Italiano per lo Studio della Sopravvivenza nell'Infarto Miocardico (GISSI-2). N Engl J Med 1993; 329 : 1442–1448. Article CAS Google Scholar Senneff MJ, Geltmann EM, Bergmann SR, Hartman J : Delineation of the effects of moderate aging on myocardial perfusion. J Nucl Med 1991; 32 : 2037–2042. CAS PubMed Google Scholar Uren NG, Camici PG, Melin JA, et al : Effect of aging on myocardial perfusion reserve. J Nucl Med 1995; 36 : 2032–2036. CAS PubMed Google Scholar Richer C, Gervais M, Fornes P, Guidicelli JF : Combined selective angiotensin II AT1-receptor blockade and angiotensin I–converting enzyme inhibitor on coronary flow reserve in postischemic heart failure in rats. J Cardiovasc Pharmacol 1999; 34 : 772–781. Article CAS Google Scholar Download references
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Kazuhiro Yamamoto (2008) studied this question.
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