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New-onset atrial fibrillation and chronic coronary syndrome in the CLARIFY registry
Why the study?
Data on new-onset atrial fibrillation in patients with chronic coronary syndromes are scarce.
Does new-onset atrial fibrillation increase the risk of adverse cardiovascular outcomes in patients with chronic coronary syndromes?
Population
29 001 CCS outpatients without previously reported AF at baseline across 45 countries
Comparison
At least one episode of AF/flutter during follow-up vs remaining in sinus rhythm
Design
International prospective observational longitudinal registry
Follow-up
5-year
Authors
Discussion
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Member takes
Implication
Alerts clinicians to heightened MACE risk after new-onset AF in chronic coronary syndromes; extends prior cohorts but remains hypothesis-generating.
Structured PICO
Does new-onset atrial fibrillation increase the risk of adverse cardiovascular outcomes in patients with chronic coronary syndromes?
P
Population
29,001 outpatients with chronic coronary syndromes (CCS) without previously reported atrial fibrillation at baseline
I
Intervention
New-onset atrial fibrillation (NOAF) diagnosed during 5-year follow-up
C
Comparator
Patients remaining in sinus rhythm throughout the 5-year follow-up
O
Outcome
Composite of cardiovascular death, non-fatal myocardial infarction, or non-fatal strokecomposite
New-onset atrial fibrillation occurs in 5% of patients with chronic coronary syndromes over 5 years and is associated with a doubled risk of major adverse cardiovascular events.
Cite This Study
Gautier et al. (2023) studied this question.