What question did this study set out to answer?

To establish a micropuncture technique for accessing deep renal cortical structures and measure glomerular capillary pressure across cortical depths in the rat kidney.

December 1, 1977Acta Physiologica Scandinavica

Capillary Pressure in Deep and Superficial Glomeruli of the Rat Kidney

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To establish a micropuncture technique for accessing deep renal cortical structures and measure glomerular capillary pressure across cortical depths in the rat kidney.
Immobilized the left rat kidney in a lucite cup and excised a 1–2 mm thick dorsal slice to expose up to 40 circulating glomeruli for direct micropuncture.
Measured glomerular capillary pressure (PG) and Bowman's capsule pressure via servo-controlled counter pressure in Wistar and Sprague Dawley rats under Inactin or Membumal anesthesia.
Average PG was 57.8 ± 1.4 mmHg (n=41) in Inactin-anesthetized Wistar rats, 58.1 ± 1.3 mmHg (n=13) under Membumal anesthesia, and 58.1 ± 1.7 mmHg (n=14) in Sprague Dawley rats.
In Wistar rats, PG was 57.9 ± 1.8 mmHg (n=20) at depth ≤0.4 mm, 60.5 ± 1.5 mmHg (n=20) at 0.5–0.9 mm, and 53.8 ± 2.5 mmHg (n=13) at ≥1.0 mm, while Bowman's capsule pressure averaged 11.2 ± 0.6 mmHg (n=30).

Authors

KAKnut AuklandUppsala University KTK. Heyeraas TønderUniversity of Bergen GNGrethe NæssInnlandet Hospital Trust

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Implication

Micropuncture study reveals elevated capillary pressure across cortical depths in rats, suggesting that glomerular filtration equilibrium is not reached.

Cite This Study

Aukland et al. (1977) studied this question.

synapsesocial.com/papers/6a7ebfd2dd8171d0d19a19de https://doi.org/10.1111/j.1748-1716.1977.tb06025.x

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Implication

Micropuncture study reveals elevated capillary pressure across cortical depths in rats, suggesting that glomerular filtration equilibrium is not reached.

Capillary Pressure in Deep and Superficial Glomeruli of the Rat Kidney

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Discussion

Implication

Cite This Study

Capillary Pressure in Deep and Superficial Glomeruli of the Rat Kidney

Key Points

Discussion

Implication

Cite This Study

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