Why the study?
Does single oral dose irbesartan reduce blood pressure and alter hormonal responses in salt-deplete healthy men compared to placebo?
Population
12 healthy, normotensive male volunteers following a standardised salt-depletion regimen for 3 days before…
Comparison
Single oral doses of irbesartan vs Placebo
Design
RCT, randomised in each panel, double-blind
Follow-up
24 hours post-dose
Authors
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Supports acute BP reduction with irbesartan in salt-deplete men; confirms expected AT1 blockade pharmacodynamics in humans.
Does single oral dose irbesartan reduce blood pressure and alter hormonal responses in salt-deplete healthy men compared to placebo?
Irbesartan demonstrates dose-dependent blood pressure reduction and expected hormonal responses characteristic of AT1 receptor antagonists in salt-deplete healthy men.
McIntyre et al. (1996) studied this question.
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