NO generation and action during changes in salt intake: roles of nNOS and macula densa

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Population

Groups of rats (n = 6-10 per group) equilibrated to high-salt (HS) or low-salt (LS) diets

Comparison

7-nitroindazole or furosemide with volume… vs Vehicle (Veh)

Design

Preclinical

Authors

Discussion

Animal data link nNOS to salt-induced NO excretion; hypothesis-generating for human salt sensitivity without clinical implications.

Population

Groups of rats (n = 6-10 per group) equilibrated to high-salt (HS) or low-salt (LS) diets

Intervention

7-nitroindazole (7-NI) or furosemide (F) with volume replacement, and NG-nitro-L-arginine methyl ester (L-NAME)

Comparator

Vehicle (Veh)

Outcome

Excretion of NO metabolites (NO2 plus NO3, NOX) and renal vascular resistance (RVR)surrogate

High salt intake increases NO generation and renal action dependent on nNOS and macula densa solute reabsorption compared to salt restriction.

Wilcox et al. (1998) studied this question.

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