What question did this study set out to answer?

To evaluate the molecular mechanisms, preclinical evidence, and clinical efficacy of vitamin D in controlling the growth and development of uterine fibroids.

August 14, 2026CureusOpen Access

Influence of Vitamin D on the Growth and Development of Uterine Fibroids

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Authors

NANoura E AwadFachhochschule Kiel

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Implication

Systematic review demonstrates that vitamin D inhibits uterine fibroid growth by modulating hormone receptors in reproductive-aged women, suggesting a safe, cost-effective therapeutic option.

Key Points

To evaluate the molecular mechanisms, preclinical evidence, and clinical efficacy of vitamin D in controlling the growth and development of uterine fibroids.
Conducted a systematic review following PRISMA guidelines searching PubMed Central and Google Scholar from inception through July 2023–2025.
Included peer-reviewed in vitro assays, in vivo animal models, and human clinical trials evaluating vitamin D's relationship with uterine leiomyoma.
Evaluated study quality using Cochrane RoB 2, Newcastle-Ottawa Scale, and SYRCLE tools, synthesizing findings via narrative review due to methodological heterogeneity.
Vitamin D deficiency strongly correlates with uterine fibroid presence across demographic and high-risk populations.
Preclinical in vitro and in vivo models show vitamin D suppresses leiomyoma cell proliferation, reduces DNA damage, and downregulates estrogen and progesterone receptor expression.
Clinical trials confirm that vitamin D supplementation promotes the regression of fibroid size and total volume without significant adverse effects.

Cite This Study

Noura E Awad (2026) studied this question.

synapsesocial.com/papers/6a7ec6c6b70b84ec8b912df2 https://doi.org/10.7759/cureus.114365

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Implication

Systematic review demonstrates that vitamin D inhibits uterine fibroid growth by modulating hormone receptors in reproductive-aged women, suggesting a safe, cost-effective therapeutic option.

Influence of Vitamin D on the Growth and Development of Uterine Fibroids

Discussion

Member takes

Implication

Key Points

Cite This Study

Influence of Vitamin D on the Growth and Development of Uterine Fibroids

Discussion

Member takes

Implication

Key Points

Cite This Study

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