High prevalence of vitamin D deficiency in Pakistan and its relation to uterine fibroids development and progression

Vitamin D insufficiency is a condition that affects more than a billion individuals globally and is escalating in prevalence. According to Riaz et al., 31.2% of Pakistan’s population had low vitamin D levels, while 53.5% of the country’s population had deficiencies. Recent research suggests that vitamin D insufficiency, a severe health problem with numerous effects, including a higher risk of female reproductive malignancies, may have an impact on the growth and progression of uterine leiomyomas. The most prevalent benign pelvic tumor, uterine fibroids, do not have an effective long-term medical solution. Surgery, such as hysterectomy and myomectomy, is currently the most common type of treatment for symptomatic UFs; however, these procedures increase the risk of an operation’s complications for patients and are exceedingly expensive for healthcare systems.The key is that vitamin D supplements can be utilized to prevent, treat, or reduce the size of UF and that vitamin D insufficiency is a significant risk factor for the onset and progression of UF. As a result, there is an urgent need to promote vitamin D supplementation as a prospective treatment for uterine fibroids and to fill the gap left by the lack of non-invasive options.