What question did this study set out to answer?

To evaluate the safety, operative risks, and strategy-level outcomes of early versus delayed laparoscopic cholecystectomy for acute calculous cholecystitis.

August 14, 2026CureusOpen Access

Early Versus Delayed Laparoscopic Cholecystectomy for Acute Calculous Cholecystitis: A Systematic Review

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Authors

AHAbeer Ali A HakamiUniversidad Complutense de Madrid MSMaryam A SultanIsfahan University of Medical Sciences HHHajar Ahmed Hakami

Discussion

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Implication

Systematic review reveals that early laparoscopic cholecystectomy reduces composite morbidity and hospital stay in acute cholecystitis, suggesting immediate surgery is safe.

Key Points

To evaluate the safety, operative risks, and strategy-level outcomes of early versus delayed laparoscopic cholecystectomy for acute calculous cholecystitis.
Searched PubMed, Cochrane Library, Scopus, and Web of Science through June 2026 following PRISMA 2020 guidelines.
Included 17 studies (11 randomized controlled trials and 6 observational studies), synthesizing RCTs using DerSimonian-Laird random-effects models and evaluating bias via RoB 2 and ROBINS-I.
Early laparoscopic cholecystectomy showed no significant increase in conversion to open surgery (OR 0.90, 95% CI 0.58–1.38; I² = 0%), bile leak (OR 1.80, 95% CI 0.69–4.66), bile duct injury (OR 0.61, 95% CI 0.15–2.48), mortality (OR 0.94, 95% CI 0.21–4.17), or postoperative complications (OR 0.73, 95% CI 0.38–1.40).
Composite strategy morbidity was significantly lower with early surgery (OR 0.26, 95% CI 0.17–0.38; p < 0.001; I² = 0%), and total hospital stay was reduced by 3 to 6 days across all 11 RCTs.

Cite This Study

Hakami et al. (2026) studied this question.

synapsesocial.com/papers/6a7ec707b70b84ec8b9131a2 https://doi.org/10.7759/cureus.114352

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Implication

Systematic review reveals that early laparoscopic cholecystectomy reduces composite morbidity and hospital stay in acute cholecystitis, suggesting immediate surgery is safe.

Early Versus Delayed Laparoscopic Cholecystectomy for Acute Calculous Cholecystitis: A Systematic Review

Discussion

Member takes

Implication

Key Points

Cite This Study

Early Versus Delayed Laparoscopic Cholecystectomy for Acute Calculous Cholecystitis: A Systematic Review

Discussion

Member takes

Implication

Key Points

Cite This Study

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