What question did this study set out to answer?

To compare the efficacy and safety of flexible ureteroscopy (FURS) versus minipercutaneous nephrolithotomy (mPCNL) for the management of 2 to 4 cm kidney stones.

August 14, 2026Journal of Endourology

Flexible Ureteroscopy Versus Minipercutaneous Nephrolithotomy for 2 to 4 cm Renal Stones: A Systematic Review and Meta-Analysis

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Authors

MSM. SaadAl-Azhar University ANAya M. NasrAlexandria University TKTasbih Fawzi KeshkAl-Azhar University

Discussion

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Implication

Systematic review and meta-analysis demonstrates lower complication rates with flexible ureteroscopy compared to mini-PCNL for 2 to 4 cm renal stones, indicating superior surgical safety.

Key Points

To compare the efficacy and safety of flexible ureteroscopy (FURS) versus minipercutaneous nephrolithotomy (mPCNL) for the management of 2 to 4 cm kidney stones.
Conducted a systematic review and meta-analysis adhering to PRISMA guidelines across electronic databases for randomized controlled trials and observational studies.
Included 20 studies evaluating a total of 2,326 adult patients with large renal stones measuring 2 to 4 cm.
Stone-free rates showed no significant difference between FURS and mPCNL (MD = 0.98, 95% CI [0.95, 1.01], p = 0.1330).
FURS was associated with a significant reduction in overall complication rates (RR = 0.52, 95% CI [0.41, 0.65], p < 0.0001) and blood transfusion rates (RD = -0.02, 95% CI [-0.03, -0.01], p = 0.0013).
Hospital stays were significantly shorter (MD = -57.10, 95% CI [-84.10, -30.11], p < 0.0001) and hemoglobin drop was lower (MD = -0.75, 95% CI [-1.42, -0.07], p = 0.03) with FURS compared to mPCNL.

Cite This Study

Saad et al. (2026) studied this question.

synapsesocial.com/papers/6a7ec71db70b84ec8b913312 https://doi.org/10.1177/08927790261475450

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Implication

Systematic review and meta-analysis demonstrates lower complication rates with flexible ureteroscopy compared to mini-PCNL for 2 to 4 cm renal stones, indicating superior surgical safety.

Flexible Ureteroscopy Versus Minipercutaneous Nephrolithotomy for 2 to 4 cm Renal Stones: A Systematic Review and Meta-Analysis

Discussion

Member takes

Implication

Key Points

Cite This Study

Flexible Ureteroscopy Versus Minipercutaneous Nephrolithotomy for 2 to 4 cm Renal Stones: A Systematic Review and Meta-Analysis

Discussion

Member takes

Implication

Key Points

Cite This Study

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