What question did this study set out to answer?

To evaluate the long-term safety and survival outcomes of autologous stem cell transplantation (ASCT) as consolidation therapy in fit patients aged ≥60 years with acute myeloid leukemia in first complete remission.

August 14, 2026Hematology ReportsOpen Access

Is There Still a Role for Autologous Stem Cell Transplantation in Older Adults with AML?

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Authors

SCSaveria CapriaSapienza University of Rome CMClara MinottiPoliclinico Umberto I MBMassimo BrecciaSapienza University of Rome

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Implication

Retrospective multicenter study reveals favorable long-term survival with low mortality after autologous stem cell transplantation in older AML patients, indicating its feasibility as consolidation.

Key Points

To evaluate the long-term safety and survival outcomes of autologous stem cell transplantation (ASCT) as consolidation therapy in fit patients aged ≥60 years with acute myeloid leukemia in first complete remission.
Retrospective analysis of N=43 non-M3 acute myeloid leukemia patients (median age 64 years, range 60–72) in first complete remission across five centers between 2000 and 2024.
Patients were stratified into favorable-risk (N=22) and intermediate-risk (N=21) cohorts using ELN 2017 criteria, with overall survival (OS) and disease-free survival (DFS) evaluated at a median follow-up of 77 months.
At a median follow-up of 77 months, the 5-year OS was 51% (95% CI: 37–70%) and 5-year DFS was 47% (95% CI: 34–65%).
5-year OS was significantly higher in favorable-risk compared to intermediate-risk patients (68% vs. 35%, p = 0.027), with a similar trend for DFS (57% vs. 35%, p = 0.07).
Transplant-related mortality was 4%, grade III/IV infections occurred in 28% of patients, and median neutrophil and platelet engraftment occurred at 13 and 15 days, respectively.

Cite This Study

Capria et al. (2026) studied this question.

synapsesocial.com/papers/6a7ec764b70b84ec8b913bc5 https://doi.org/10.3390/hematolrep18040057

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Implication

Retrospective multicenter study reveals favorable long-term survival with low mortality after autologous stem cell transplantation in older AML patients, indicating its feasibility as consolidation.

Is There Still a Role for Autologous Stem Cell Transplantation in Older Adults with AML?

Discussion

Member takes

Implication

Key Points

Cite This Study

Is There Still a Role for Autologous Stem Cell Transplantation in Older Adults with AML?

Discussion

Member takes

Implication

Key Points

Cite This Study

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