Key result
Confirmed fetal CMV infection accounts for ~4% of fetal demises following positive maternal testing.
Why the study?
Severe congenital CMV can lead to fetal demise, prompting the need to quantify and characterize confirmed CMV infection among fetal demises.
Population
61,973 recorded pregnancies, including 1173 fetal demises, at a pediatric hospital in the US
Design
Retrospective cohort study
Authors
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CMV testing may identify cases among fetal demises; leaves open whether routine screening alters outcomes.
Cohort (n=61,973)
No
CMV infection is a measurable cause of fetal demise, particularly among CMV IgM-positive pregnancies, highlighting the need for improved screening.
Rochat et al. (2026) conducted a cohort in Fetal demise and congenital CMV infection (n=61,973). Maternal CMV infection vs. No maternal CMV infection was evaluated on Fetal demise directly attributable to CMV. Among 94 fetal demises with positive maternal CMV testing and complete records, 4 (4%) were directly attributable to confirmed fetal CMV infection.
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