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August 14, 2026Journal of Applied Polymer Science

Optimization, Characterization, and In Vitro Evaluation of Fusidic Acid‐Hydroxypropyl β‐Cyclodextrin Polymeric Complex Encapsulated Within a pH and Thermo‐Responsive N‐Isopropylacrylamide‐Itaconic Acid Nanogel

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Authors

AMAzizullah MukhtarWAWaqas AhmadHAHassan Ali

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Overview

In vitro study demonstrates controlled topical antibiotic release from a dual pH- and thermo-responsive nanogel, highlighting its potential to combat bacterial skin infections and resistance.

Key Points

  • To develop and evaluate a dual pH- and temperature-responsive nanogel system encapsulating a fusidic acid-hydroxypropyl-beta-cyclodextrin inclusion complex for enhanced solubility and controlled topical antibiotic delivery.
  • Synthesized a fusidic acid-hydroxypropyl-beta-cyclodextrin (HPβCD) complex to enhance drug solubility.
  • Fabricated N-isopropylacrylamide-itaconic acid (NIPAM-IA) nanogels via free radical polymerization to encapsulate the inclusion complex.
  • Characterized formulations using FTIR, DSC-TGA, swelling behavior assays across pH levels, and in vitro kinetic drug release modeling.
  • The optimized formulation (NIB-7) achieved a drug entrapment efficiency of 75.1% ± 1.7% and demonstrated 600% ± 3.0% swelling at pH 7.4 compared to 109.5% ± 3.0% at pH 1.2.
  • In vitro release reached 76.5% ± 4.5% cumulative antibiotic release over 48 hours, demonstrating sustained retention compared to unencapsulated control.
  • Release kinetics conformed to anomalous (non-Fickian) transport (n = 0.68, R² = 0.95), driven by drug diffusion and polymer network swelling responses.

Cite This Study

Mukhtar et al. (2026) studied this question.

synapsesocial.com/papers/6a7ec79cb70b84ec8b9141e3https://doi.org/10.1002/app.71301
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