What question did this study set out to answer?

To synthesize and characterize a temperature- and pH-responsive interpenetrating polymer network hydrogel based on PNIPAm and sodium alginate for controlled, sustained intestinal drug delivery.

August 14, 2026Journal of Applied Polymer Science

Preparation and Sustained Drug Release Study of Interpenetrating Network PNIPAm / SA (Ca 2+ ) Hydrogels

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Authors

JLJiaxin Liu YGYuhua Gao ZXZhice Xu

Discussion

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Overview

In vitro study demonstrates targeted 5-fluorouracil release and biodegradability from dual-responsive hydrogels, highlighting potential for small intestine therapies.

Key Points

To synthesize and characterize a temperature- and pH-responsive interpenetrating polymer network hydrogel based on PNIPAm and sodium alginate for controlled, sustained intestinal drug delivery.
Synthesized an aminoethyl-modified polyaspartic acid derivative (AEA-PSI) as a crosslinking agent and characterized it using 1H NMR and FTIR.
Formulated hydrogels by systematically adjusting sodium alginate content, NIPAm concentration, and AEA-PSI crosslinker dosage, with structural verification via SEM, XPS, TGA, and MIP.
Evaluated in vitro drug release kinetics using 5-fluorouracil in simulated gastric (pH 1.2) and intestinal (pH 7.4) fluids alongside degradation assays in lysozyme solution.
Optimized hydrogels achieved 90.19% 5-fluorouracil release in simulated intestinal fluid (pH 7.4) versus minimal release in simulated gastric fluid (pH 1.2), fitting the Ritger–Peppas kinetic model.
Incorporating AEA-PSI tailored the three-dimensional porous network and swelling capacity without compromising dual pH- and temperature-responsiveness.
Formulations exhibited enhanced biodegradability in simulated intestinal fluid and lysozyme compared to conventional alginate networks.

Cite This Study

Liu et al. (2026) studied this question.

synapsesocial.com/papers/6a7ee587b70b84ec8b914728 https://doi.org/10.1002/app.71339

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August 14, 2026Journal of Applied Polymer Science

Preparation and Sustained Drug Release Study of Interpenetrating Network PNIPAm / SA (Ca 2+ ) Hydrogels

View Full Paper

Ask AI

Bookmark

Authors

JLJiaxin Liu YGYuhua Gao ZXZhice Xu

Discussion

Member takes

Overview

In vitro study demonstrates targeted 5-fluorouracil release and biodegradability from dual-responsive hydrogels, highlighting potential for small intestine therapies.

Key Points

To synthesize and characterize a temperature- and pH-responsive interpenetrating polymer network hydrogel based on PNIPAm and sodium alginate for controlled, sustained intestinal drug delivery.
Synthesized an aminoethyl-modified polyaspartic acid derivative (AEA-PSI) as a crosslinking agent and characterized it using 1H NMR and FTIR.
Formulated hydrogels by systematically adjusting sodium alginate content, NIPAm concentration, and AEA-PSI crosslinker dosage, with structural verification via SEM, XPS, TGA, and MIP.
Evaluated in vitro drug release kinetics using 5-fluorouracil in simulated gastric (pH 1.2) and intestinal (pH 7.4) fluids alongside degradation assays in lysozyme solution.
Optimized hydrogels achieved 90.19% 5-fluorouracil release in simulated intestinal fluid (pH 7.4) versus minimal release in simulated gastric fluid (pH 1.2), fitting the Ritger–Peppas kinetic model.
Incorporating AEA-PSI tailored the three-dimensional porous network and swelling capacity without compromising dual pH- and temperature-responsiveness.
Formulations exhibited enhanced biodegradability in simulated intestinal fluid and lysozyme compared to conventional alginate networks.

Cite This Study

Liu et al. (2026) studied this question.

synapsesocial.com/papers/6a7ee587b70b84ec8b914728 https://doi.org/10.1002/app.71339

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