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March 25, 2026GelsOpen Access

Protein-Modulated Stimuli-Responsive Hydrogels Based on Methacrylated Bovine Serum Albumin and pNIPAm: pH- and Temperature-Dependent Drug Release Behavior

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Authors

MBMehmet Bostan

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Overview

Demonstrates protein-modulated hydrogels improve drug release in gastrointestinal systems, suggesting effective cancer therapy options.

Key Points

  • The aim was to develop dual-responsive hydrogels for controlled drug release in cancer therapy.
  • Synthesized MeBSA using glycidyl methacrylate and characterized it with FTIR and 1H-NMR.
  • Prepared hydrogels with varying MeBSA/NIPA ratios via redox polymerization.
  • Conducted swelling studies at different temperatures and pH levels to assess responsiveness.
  • Performed in vitro release studies of 5-FU at 37 °C to evaluate drug release profiles.
  • Assessed cytocompatibility through fibroblast viability tests.
  • Drug loading efficiencies exceeding 70% for all formulations.
  • Initial limited drug release without burst effect observed under acidic conditions.
  • Cumulative drug release varied by composition, with GEL 4 achieving 91% and GEL 1 sustaining 32% release over 72 hours.
  • Release kinetics were best described by Weibull and Korsmeyer–Peppas models.
  • Fibroblast viability improved with increased MeBSA content.

Cite This Study

Mehmet Bostan (2026) studied this question.

synapsesocial.com/papers/69c37acab34aaaeb1a67ca5fhttps://doi.org/10.3390/gels12030263
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