What does this research mean for the field?

Poly(N-acryloyl glycine) (PNAG) microgels exhibit strong pH- and calcium-responsive structural changes that enable high drug payloads (>20 wt.%) and prolonged diffusion-controlled release of biopharmaceuticals for up to two weeks. Novelty: ClaimNovelty.INCREMENTAL. Consensus alignment: ConsensusAlignment.NEUTRAL.

What question did this study set out to answer?

To synthesize dual-stimuli responsive poly(N-acryloyl glycine) microgels via droplet microfluidics and evaluate their network dynamics for biologic drug encapsulation and controlled release.

August 22, 2026SmallOpen Access

Dual‐Stimuli Responsive Poly( N ‐acryloyl glycine) Microgels: Investigation of Network Structures and Application for Loading and Release of Biologics

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Authors

YDYusuf DursunMartin Luther University Halle-Wittenberg BABurak AydinBezmiâlem Vakıf Üniversitesi BLBidit LamsalMartin Luther University Halle-Wittenberg

Discussion

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Implication

Experimental study demonstrates dual pH- and ion-triggered cargo entrapment in PNAG microgels, suggesting potential for sustained biopharmaceutical release.

Key Points

To synthesize dual-stimuli responsive poly(N-acryloyl glycine) microgels via droplet microfluidics and evaluate their network dynamics for biologic drug encapsulation and controlled release.
Fabricated PNAG microgel particles using droplet-based microfluidics coupled with in situ photopolymerization.
Optimized gelation kinetics and evaluated network constraints across pH levels (3, 7.4, 9) and CaCl2 concentrations (0 or 5 wt.%) using rheology and multiple-quantum NMR.
Loaded glutathione (GSH) into microgels via pH-induced swelling, entrapped the cargo via Ca2+-induced network constriction, and monitored in vitro release kinetics.
Microparticles showed dynamic swelling responses with volume increases exceeding 5000 vol.% following pH shifts.
Ca2+-induced network constriction following soaking enabled high drug entrapment payloads exceeding 20 wt.% for model biopharmaceuticals.
Release profiling demonstrated an initial burst release followed by sustained, diffusion-controlled drug release spanning approximately two weeks.

Cite This Study

Dursun et al. (2026) studied this question.

synapsesocial.com/papers/6a898131ca7ade938187f35e https://doi.org/10.1002/smll.75268

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Implication

Experimental study demonstrates dual pH- and ion-triggered cargo entrapment in PNAG microgels, suggesting potential for sustained biopharmaceutical release.

Dual‐Stimuli Responsive Poly( N ‐acryloyl glycine) Microgels: Investigation of Network Structures and Application for Loading and Release of Biologics

Discussion

Member takes

Implication

Key Points

Cite This Study

Dual‐Stimuli Responsive Poly( N ‐acryloyl glycine) Microgels: Investigation of Network Structures and Application for Loading and Release of Biologics

Discussion

Member takes

Implication

Key Points

Cite This Study

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