Development of Soft Graphene Electrodes for Label-Free Cell Measurements Using Non-Faradaic Electrochemical Impedance Spectroscopy

Emil Fuhry

doi:10.18452/37844

August 12, 2026Open Access

Development of Soft Graphene Electrodes for Label-Free Cell Measurements Using Non-Faradaic Electrochemical Impedance Spectroscopy

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Key Points

Develop soft, physiologically biomimetic graphene electrodes with tunable mechanical stiffness for label-free, real-time electrochemical cell sensing.
Optimized graphene transfer onto polydimethylsiloxane (PDMS) substrates using an automated AI-assisted optical microscopy evaluation system.
Tuned PDMS cross-linking density to adjust electrode stiffness (measured by atomic force microscopy) and monitored MCF-7 epithelial cell adhesion using impedance spectroscopy and optical microscopy.
Assessed potential-dependent sensitivity using silicon microparticles as a cell adhesion model via real-time potentiodynamic electrochemical impedance spectroscopy.
AI-guided optimization of graphene transfer achieved a median defect-free surface coverage of 99.8%.
Electrode elastic modulus was successfully tuned across a range of 10 to 60 MPa without compromising soft substrate mechanics or electrochemical performance.
Non-Faradaic electrochemical impedance measurements demonstrated maximum sensing sensitivity when operated near the potential of zero charge.

Implication

In vitro experimental study demonstrates real-time cell adhesion monitoring on tunable soft graphene electrodes, indicating optimal sensitivity near the potential of zero charge.

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Cite This Study

Emil Fuhry (2026) studied this question.

synapsesocial.com/papers/6a7ec79cb70b84ec8b914257 https://doi.org/10.18452/37844

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Development of Soft Graphene Electrodes for Label-Free Cell Measurements Using Non-Faradaic Electrochemical Impedance Spectroscopy

Key Points

Implication

Abstract

Discussion

Cite This Study

Development of Soft Graphene Electrodes for Label-Free Cell Measurements Using Non-Faradaic Electrochemical Impedance Spectroscopy

Key Points

Implication

Abstract

Discussion

Cite This Study

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